AKAPs regulate primary cilia growth
Primary cilia are “cellular antennae” and signaling hubs that amplify and integrate multiple chemical inputs such as calcium and cyclic AMP signaling responses within their specialized organellar environment. Ciliopathies are a group of disorders associated with genetic mutations in proteins, that result in either abnormal formation or function of cilia. Hence, understanding which second messenger responsive enzymes are incorporated into ciliary AKAP signaling islands are currently topics of considerable research interest. An important element of this research is the ability to image ciliary action and movement in real time.