CELL SIGNALING IN SPACE AND TIME
Cells respond to environmental cues by mobilizing signal transduction enzymes. Spatial organization provided by scaffolding proteins guides this flow of molecular information to particular subcellular sites.
The Scott lab researches how spatial organization of key regulatory enzymes influences cellular behavior. They have pioneered the investigation of A-Kinase Anchoring proteins (AKAPs), a burgeoning family of organizational proteins that precisely position cell signaling enzymes inside cells. A multidisciplinary team of biochemists, cell biologists and pharmacologists work closely with physicians to investigate what happens when AKAP signaling goes awry in diseases such as endocrine disorders, cardiovascular disease, and adolescent cancers.
Latest John D. Scott Lab News
Maryanne Kihiu awarded a 2023 AHA Predoctoral Fellowship
Thursday, June 29, 2023 – 11:00am, K-069 Molecular Interactions and Signaling Mechanisms of the Oncogenic Fusion Protein DNAJ-PKAc in Fibrolamellar Carcinoma
ASPET recently announced a new class of Fellows to honor our most distinguished members. Selection as a Fellow of the American Society for Pharmacology and Experimental Therapeutics (FASPET) is an honor bestowed to our most distinguished members. Fellows are recognized for their meritorious efforts to advance pharmacology, through their scientific achievements, mentorship, and service to...
Spatial biology is a new frontier and a central focus of the Scott lab in the department of pharmacology